Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria–nucleus signalling

30 Sept 2011

Abstract excerpt

Over the past two decades, a complex nuclear transcriptional machinery controlling mitochondrial biogenesis and function has been described. Central to this network are the PGC-1 family coactivators, characterised as master regulators of mitochondrial biogenesis. Recent literature has identified a broader role for PGC-1 coactivators in both cell death and cellular adaptation under conditions of stress, here...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to ATP Synthase and ATPases Research
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21983689
DOI: 10.1016/j.mito.2011.09.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria–nucleus signallingPMID 21983689Read ↗

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA MaintenanceSemantic proximity Read ↗

PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular MetabolismSemantic proximity Read ↗

Transcriptional Control of Mitochondrial Biogenesis and FunctionSemantic proximity Read ↗

Mitochondrial Biogenesis in Health and Disease. Molecular and Therapeutic ApproachesSemantic proximity Read ↗

Mitochondrial content is central to nuclear gene expression: Profound implications for human healthSemantic proximity Read ↗

Mitochondrial-epigenetic crosstalk in environmental toxicology.Semantic proximity Read ↗

Mitochondria and cancer.Semantic proximity Read ↗

Dysregulation of PGC-1α-Dependent Transcriptional Programs in Neurological and Developmental Disorders: Therapeutic Challenges and OpportunitiesSemantic proximity Read ↗

Mitochondrial pathology: stress signals from the energy factorySemantic proximity Read ↗

Extranuclear Localization of SIRT1 and PGC-1α: An Insight into Possible Roles in Diseases Associated with Mitochondrial DysfunctionSemantic proximity Read ↗

The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease.Semantic proximity Read ↗

Beyond retrograde and anterograde signalling: mitochondrial-nuclear interactions as a means for evolutionary adaptation and contemporary disease susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.