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Article

Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway.

Cell death & disease - 10 Feb 2021

Liu Xiaoli, Yin Zuwei, Xu Linping, Liu Huaimin, Jiang Lifeng, Liu Shuochuan, Sun Xu

Abstract excerpt

Long noncoding RNAs (lncRNAs) play crucial roles in regulating a variety of biological processes in lung adenocarcinoma (LUAD). In our study, we mainly explored the functional roles of a novel lncRNA long intergenic non-protein coding RNA 1426 (LINC01426) in LUAD. We applied bioinformatics analysis to find the expression of LINC01426 was upregulated in LUAD tissue. Functionally, silencing of LINC01426 obviously...

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Identifiers

PMID: 33568633
DOI: 10.1038/s41419-021-03435-y
PMCID: PMC7875967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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