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Article

HIF-1ɑ-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling.

Theranostics - 1 Jan 2020

Jiang Neng, Zou Chang, Zhu Ying, Luo Yifeng, Chen Lili, Lei Yiyan, Tang Kejing, Sun Yu, Zhang Wenhui, Li Shuhua, He Qiong, Zhou Jianwen, Chen Yangshan, Luo Jiping, Jiang Wenting, Ke Zunfu

Abstract excerpt

Rationale: Cancer stem cells (CSCs) are considered to be essential for tumorigenesis, recurrence, and metastasis and therefore serve as a biomarker for tumor progression in diverse cancers. Recent studies have illustrated that specific miRNAs exhibit novel therapeutic potential by controlling CSC properties. miR-1275 is upregulated in lung adenocarcinoma (LUAD) and enhances its stemness. However, the underlying...

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Share to Adenocarcinoma of Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Neoplasm Recurrence, Local

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Identifiers

PMID: 32194819
DOI: 10.7150/thno.41120
PMCID: PMC7052895

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