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Screening of Graves' disease susceptibility genes by whole exome sequencing in a three-generation family.

BMC medical genomics - 10 Feb 2021

Hu Zhuoqing, Li Wei, Li Miaosheng, Wei Hao, Hu Zhihui, Chen Yanting, Luo Ai, Li Wangen

Abstract excerpt

BACKGROUND: Graves' disease(GD) has a tendency for familial aggregation, but it is uncommon to occur in more than two generations. However, little is known about susceptibility genes for GD in the three-generation family. METHODS: DNA were extracted from three-generation familial GD patient with a strong genetic background in a Chinese Han population. The Whole Exome Sequencing (WES) was utilized to screen the...

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PMID: 33568133
DOI: 10.1186/s12920-020-00865-z
PMCID: PMC7874465

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