Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Delivery is key: lessons learnt from developing splice‐switching antisense therapies

13 Mar 2017

Abstract excerpt

The use of splice-switching antisense therapy is highly promising, with a wealth of pre-clinical data and numerous clinical trials ongoing. Nevertheless, its potential to treat a variety of disorders has yet to be realized. The main obstacle impeding the clinical translation of this approach is the relatively poor delivery of antisense oligonucleotides to target tissues after systemic delivery. We are a group of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28289078
DOI: 10.15252/emmm.201607199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Delivery is key: lessons learnt from developing splice‐switching antisense therapiesPMID 28289078Read ↗

Expansion of Splice-Switching Therapy with Antisense OligonucleotidesSemantic proximity Read ↗

Therapeutic Potential of Splice-Switching OligonucleotidesSemantic proximity Read ↗

Antisense oligonucleotides and their applications in rare neurological diseasesSemantic proximity Read ↗

Splice-switching antisense oligonucleotides as therapeutic drugsSemantic proximity Read ↗

Practical Recommendations for the Selection of Patients for Individualized Splice-Switching ASO-Based TreatmentsSemantic proximity Read ↗

Development of Therapeutic Splice-Switching OligonucleotidesSemantic proximity Read ↗

Antisense-mediated splice intervention to treat human disease: the odyssey continuesSemantic proximity Read ↗

Translational and Regulatory Challenges for Exon Skipping TherapiesSemantic proximity Read ↗

Making antisense of splicing.Semantic proximity Read ↗

Translational development of splice-modifying antisense oligomersSemantic proximity Read ↗

Targeting Splicing in the Treatment of Human DiseaseSemantic proximity Read ↗

The Versatile Applications of Antisense Oligonucleotides in Modern MedicineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.