Article
An interdependence between GAPVD1 gene polymorphism, expression level and response to interferon beta in patients with multiple sclerosis.
Journal of neuroimmunology - 15 Apr 2021
Khademi Bahareh, Khorrami Mehdi, Ayromlou Hormoz, Rikhtegar Reza, Moghadam Ehsan Aghaei, Tahmasebivand Mahsa, Mousavi Seyyed Reza, Kheirollahi Majid, Fakhr Fatemeh, Alizadeh-Ghodsi Mohammadreza, Emamalizadeh Babak
Abstract excerpt
Interferon-β (IFN-β) is among the first drugs used for reducing the symptoms of multiple sclerosis (MS). Many studies show that the genetic predisposition of patients might modulate their response to IFN-β treatment. In this study GAPVD1 gene expression and the genotyping of rs2291858 variant were analysed in 100 responder and 100 non-responder patients with MS treated using IFN-β. Moreover, rs2291858 genotyping...
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