Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo".

doi:10.1016/j.biomaterials.2015.05.037

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Article

Bioreactor-engineered cancer tissue-like structures mimic phenotypes, gene expression profiles and drug resistance patterns observed "in vivo".

Biomaterials - 1 Sept 2015

Hirt Christian, Papadimitropoulos Adam, Muraro Manuele G, Mele Valentina, Panopoulos Evangelos, Cremonesi Eleonora, Ivanek Robert, Schultz-Thater Elke, Droeser Raoul A, Mengus Chantal, Heberer Michael, Oertli Daniel, Iezzi Giandomenica, Zajac Paul, Eppenberger-Castori Serenella, Tornillo Luigi, Terracciano Luigi, Martin Ivan, Spagnoli Giulio C

Abstract excerpt

Anticancer compound screening on 2D cell cultures poorly predicts "in vivo" performance, while conventional 3D culture systems are usually characterized by limited cell proliferation, failing to produce tissue-like-structures (TLS) suitable for drug testing. We addressed engineering of TLS by culturing cancer cells in porous scaffolds under perfusion flow. Colorectal cancer (CRC) HT-29 cells were cultured in 2D,...

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PMID: 26051518
DOI: 10.1016/j.biomaterials.2015.05.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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