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Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas

15 Mar 2013

Abstract excerpt

Expansion of pancreatic β-cells is a key goal of diabetes research, yet induction of adult human β-cell replication has proven frustratingly difficult. In part, this reflects a lack of understanding of cell cycle control in the human β-cell. Here, we provide a comprehensive immunocytochemical "atlas" of G1/S control molecules in the human β-cell. This atlas reveals that the majority of these molecules, previously...

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PMID: 23493570
DOI: 10.2337/db12-0777

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