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Weight Loss Following Roux-en-Y Gastric Bypass Causally Implicated with Serum Levels of IL-22: A Mendelian Randomization and Phenome-Wide Association Study.

Obesity (Silver Spring, Md.) - 1 Mar 2021

Abdalla Moustafa, Jones Daniel B

Abstract excerpt

OBJECTIVE: Laparoscopic Roux-en-Y gastric bypass (RYGB) modulates the low-grade inflammatory state associated with severe obesity. This study sought to investigate whether weight loss is causally implicated with changes in serum levels of inflammatory molecules. METHODS: Using the largest genome-wide association study (n = 1,020 individuals), this study curated five genetic variants associated with weight loss...

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PMID: 33528908
DOI: 10.1002/oby.23097

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