Article
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
Gut - 1 Jan 2022
Olazagoitia-Garmendia Ane, Zhang Linda, Mera Paula, Godbout Julie K, Sebastian-DelaCruz Maialen, Garcia-Santisteban Iraia, Mendoza Luis Manuel, Huerta Alain, Irastorza Iñaki, Bhagat Govind, Green Peter H, Herrero Laura, Serra Dolors, Rodriguez Jose Antonio, Verdu Elena F, He Chuan, Bilbao Jose Ramon, Castellanos-Rubio Ainara
Abstract excerpt
OBJECTIVES: Coeliac disease (CD) is a complex autoimmune disorder that develops in genetically susceptible individuals. Dietary gluten triggers an immune response for which the only available treatment so far is a strict, lifelong gluten free diet. Human leucocyte antigen (HLA) genes and several non-HLA regions have been associated with the genetic susceptibility to CD, but their role in the pathogenesis of the...
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