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Article

Landscape of Cyclin Pathway Genomic Alterations Across 5,356 Prostate Cancers: Implications for Targeted Therapeutics.

The oncologist - 1 Apr 2021

Jardim Denis L, Millis Sherri Z, Ross Jeffrey S, Woo Michelle Sue-Ann, Ali Siraj M, Kurzrock Razelle

Abstract excerpt

The cyclin pathway may confer resistance to standard treatments but also offer novel therapeutic opportunities in prostate cancer. Herein, we analyzed prostate cancer samples (majority metastatic) using comprehensive genomic profiling performed by next-generation sequencing (315 genes, >500× coverage) for alterations in activating and sensitizing cyclin genes (CDK4 amplification, CDK6 amplification, CCND1, CCND2,...

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Identifiers

PMID: 33522043
DOI: 10.1002/onco.13694
PMCID: PMC8018295

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