Article
APOL1 risk variants affect podocyte lipid homeostasis and energy production in focal segmental glomerulosclerosis.
Human molecular genetics - 26 Apr 2021
Ge Mengyuan, Molina Judith, Ducasa G Michelle, Mallela Shamroop K, Varona Santos Javier, Mitrofanova Alla, Kim Jin-Ju, Liu Xiaochen, Sloan Alexis, Mendez Armando J, Banerjee Santanu, Liu Shaoyi, Szeto Hazel H, Shin Myung K, Hoek Maarten, Kopp Jeffrey B, Fontanesi Flavia, Merscher Sandra, Fornoni Alessia
Abstract excerpt
Lipotoxicity was recently reported in several forms of kidney disease, including focal segmental glomerulosclerosis (FSGS). Susceptibility to FSGS in African Americans is associated with the presence of genetic variants of the Apolipoprotein L1 gene (APOL1) named G1 and G2. If and how endogenous APOL1 may alter mitochondrial function by the modifying cellular lipid metabolism is unknown. Using transgenic mice...
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