Article
A case-control study examining the association of smad7 and TLR single nucleotide polymorphisms on the risk of colorectal cancer in ulcerative colitis.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland - 1 May 2021
Reilly Frank, Burke John P, Lennon Grainne, Kay Elaine W, McNamara Deborah A, Cullen Garret, Doherty Glen A, Mulcahy Hugh, Martin Sean, Winter Desmond C, Sheahan Kieran, O'Connell Patrick Ronan
Abstract excerpt
AIM: Ulcerative colitis (UC) is characterized by chronic mucosal inflammation and an increased risk of colorectal cancer. smad7, TLR2 and TLR4 modulate intestinal inflammation and their polymorphisms affect the risk of development of sporadic colorectal cancer. The aim of the current study was to examine the association between single nucleotide polymorphisms (SNPs) in smad7, TLR2 and TLR4 and the development of...
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