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Article

Two Novel Mutations of the NPM1 Gene in Syrian Adult Patients with Acute Myeloid Leukemia and Normal Karyotype.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2021

Alarbeed Ismael F, Wafa Abdulsamad, Moassass Faten, Al-Halabi Bassel, Alachkar Walid, Aboukhamis Imad

Abstract excerpt

OBJECTIVE: Somatic mutations in exon 12 of the NPM1 gene is one of the most common genetic abnormalities in adult acute myeloid leukemia (AML), which is observed in 25-35% of AML patients and in 50-60% of patients with cytogenetically normal AML (CN-AML). METHODS: We performed Sanger sequencing of exon 12 of the NPM1 gene, on 44 CN-AML patients to characterize NPM1 status. RESULTS: In this study, NPM1 mutations...

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Identifiers

PMID: 33507703
DOI: 10.31557/APJCP.2021.22.1.227
PMCID: PMC8184179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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