Article
Identification of two novel NPM1 mutations in patients with acute myeloid leukemia.
Annals of laboratory medicine - 1 Jan 2013
Jeon Yongbum, Seo Sang Won, Park Seonyang, Park Seungman, Kim So Yeon, Ra Eun Kyung, Park Sung Sup, Seong Moon-Woo
Abstract excerpt
BACKGROUND: Genetic abnormalities in adult AML are caused most frequently by somatic mutations in exon 12 of the NPM1 gene, which is observed in approximately 35% of AML patients and up to 60% of patients with cytogenetically normal AML (CN-AML). METHODS: We performed mutational analysis, including fragment analysis and direct sequencing of exon 12 of the NPM1 gene, on 83 AML patients to characterize the NPM1...
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