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Article

Cardiac-specific microRNA-125b deficiency induces perinatal death and cardiac hypertrophy.

Scientific reports - 27 Jan 2021

Chen Chen-Yun, Lee Desy S, Choong Oi Kuan, Chang Sheng-Kai, Hsu Tien, Nicholson Martin W, Liu Li-Wei, Lin Po-Ju, Ruan Shu-Chian, Lin Shu-Wha, Hu Chung-Yi, Hsieh Patrick C H

Abstract excerpt

MicroRNA-125b, the first microRNA to be identified, is known to promote cardiomyocyte maturation from embryonic stem cells; however, its physiological role remains unclear. To investigate the role of miR-125b in cardiovascular biology, cardiac-specific miR-125b-1 knockout mice were generated. We found that cardiac-specific miR-125b-1 knockout mice displayed half the miR-125b expression of control mice resulting...

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Identifiers

PMID: 33504864
DOI: 10.1038/s41598-021-81700-y
PMCID: PMC7840921

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