Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cdk5rap3 is essential for intestinal Paneth cell development and maintenance

27 Jan 2021

Abstract excerpt

Intestinal Paneth cells are professional exocrine cells that play crucial roles in maintenance of homeostatic microbiome, modulation of mucosal immunity, and support for stem cell self-renewal. Dysfunction of these cells may lead to the pathogenesis of human diseases such as inflammatory bowel disease (IBD). Cdk5 activator binding protein Cdk5rap3 (also known as C53 and LZAP) was originally identified as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Digestive system and related health
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33504792
DOI: 10.1038/s41419-021-03401-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdk5rap3 is essential for intestinal Paneth cell development and maintenancePMID 33504792Read ↗

Cyclin-Dependent Kinase 5 Regulatory Subunit Associated Protein 3: Potential Functions and Implications for Development and DiseaseSemantic proximity Read ↗

Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approachesSemantic proximity Read ↗

Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approachesSemantic proximity Read ↗

Emc3 maintains intestinal homeostasis by preserving secretory lineagesSemantic proximity Read ↗

Rspo3 regulates abnormal differentiation of small intestinal epithelial cells in diabetic stateSemantic proximity Read ↗

Large intestine embryogenesis: Molecular pathways and related disorders (Review)Semantic proximity Read ↗

Paneth cell development in the neonatal gut: pathway regulation, development, and relevance to necrotizing enterocolitisSemantic proximity Read ↗

Epithelial CRL4 DCAF2 is critical for maintaining intestinal homeostasis by regulating the proliferation and repair of intestinal epithelial cellsSemantic proximity Read ↗

Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerio.Semantic proximity Read ↗

The emerging roles of GPRC5A in diseasesSemantic proximity Read ↗

Molecular Mechanisms of Enteroendocrine DifferentiatonSemantic proximity Read ↗

YY1 is indispensable for Lgr5 <sup>+</sup> intestinal stem cell renewalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.