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Article

Re-expression of REG family and DUOXs genes in CRC organoids by co-culturing with CAFs.

Scientific reports - 22 Jan 2021

Naruse Mie, Ochiai Masako, Sekine Shigeki, Taniguchi Hirokazu, Yoshida Teruhiko, Ichikawa Hitoshi, Sakamoto Hiromi, Kubo Takashi, Matsumoto Kenji, Ochiai Atsushi, Imai Toshio

Abstract excerpt

Organoids derived from epithelial tumors have recently been utilized as a preclinical model in basic and translational studies. This model is considered to represent the original tumor in terms of 3D structure, genetic and cellular heterogeneity, but not tumor microenvironment. In this study, we established organoids and paired cancer-associated fibroblasts (CAFs) from surgical specimens of colorectal carcinomas...

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Identifiers

PMID: 33483567
DOI: 10.1038/s41598-021-81475-2
PMCID: PMC7822883

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