Article
ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking.
The Journal of biological chemistry - 1 Jan 2000
Nakato Mitsuhiro, Shiranaga Naoko, Tomioka Maiko, Watanabe Hitomi, Kurisu Junko, Kengaku Mineko, Komura Naoko, Ando Hiromune, Kimura Yasuhisa, Kioka Noriyuki, Ueda Kazumitsu
Abstract excerpt
ATP-binding cassette subfamily A member 13 (ABCA13) is predicted to be the largest ABC protein, consisting of 5058 amino acids and a long N-terminal region. Mutations in the ABCA13 gene were reported to increase the susceptibility to schizophrenia, bipolar disorder, and major depression. However, little is known about the molecular functions of ABCA13 or how they associate with psychiatric disorders. Here, we...
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