Adaptive Thermogenesis in Resistance to Obesity Therapies: Issues in Quantifying Thrifty Energy Expenditure Phenotypes in Humans.

Abstract excerpt

Dieting and exercise are likely to remain the core approaches in the management of obesity in the foreseeable future despite their well-documented failures for achieving long-term weight loss. Explanations for such poor prognosis are centered on patient's self-regulatory failure and lack of compliance to the prescribed diet or exercise regimen. While a role for physiological adaptations leading to diminished...

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