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Article

Tissue-resident macrophage inflammaging aggravates homeostasis dysregulation in age-related diseases.

Cellular immunology - 1 Mar 2021

Yue Ziqi, Nie Luningxiao, Zhang Peng, Chen Qin, Lv Qingguo, Wang Qi

Abstract excerpt

Organs and tissues contain a large number of tissue-resident macrophages (MΦ-Ts), which are essential for regulating homeostasis and ensuring a rapid response to injury. However, the environmental signals shaping MΦ-Ts phenotypes and the contribution of MΦ-Ts to pathological processes are just starting to be identified. MΦ-Ts isolated from aged animals or patients show alterations in morphology and distribution,...

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Identifiers

PMID: 33445052
DOI: 10.1016/j.cellimm.2020.104278

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