Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes

1 Jul 2021

Abstract excerpt

Mitochondria are principal metabolic organelles that are increasingly unveiled as immune regulators. However, it is currently not known whether mitochondrial-encoded peptides modulate T cells to induce changes in phenotype and function. In this study, we found that MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) prevented autoimmune β cell destruction by targeting T cells in non-obese diabetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine and Purinergic Signaling
Share to GDF15 and Related Biomarkers
Share to Macrophage Migration Inhibitory Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34320351
DOI: 10.1016/j.celrep.2021.109447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetesPMID 34320351Read ↗

MOTS-c Functionally Prevents Metabolic DisordersSemantic proximity Read ↗

Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related DiseasesSemantic proximity Read ↗

Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetesSemantic proximity Read ↗

A Pro-Diabetogenic mtDNA Polymorphism in the Mitochondrial-Derived Peptide, MOTS-cSemantic proximity Read ↗

A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c.Semantic proximity Read ↗

Mitochondrial-Encoded Peptide MOTS-c is an Exercise-Induced Regulator of Aging Metabolic Homeostasis and Physical CapacitySemantic proximity Read ↗

MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related DiseasesSemantic proximity Read ↗

Mitochondrial-derived peptides in energy metabolismSemantic proximity Read ↗

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.Semantic proximity Read ↗

The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progressionSemantic proximity Read ↗

Diabetes-associated <i>MYT1</i> and <i>ST18</i> regulate human beta-cell insulin secretion and survival via other diabetes-risk genesSemantic proximity Read ↗

Mitophagy protects beta cells from inflammatory damage in diabetesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.