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EZH1/2 Inhibitors Favor ILC3 Development from Human HSPC-CD34+ Cells

16 Jan 2021

Abstract excerpt

The dysregulation of epigenetic modifications has a well-established role in the development and progression of hematological malignancies and of solid tumors. In this context, EZH1/2 inhibitors have been designed to interfere with EZH1/2 enzymes involved in histone methylation (e.g., H3K27me3), leading to tumor growth arrest or the restoration of tumor suppressor gene transcription. However, these compounds also...

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PMID: 33467134
DOI: 10.3390/cancers13020319

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