Erythropoietin promoter polymorphism is associated with treatment efficacy and severe hematologic toxicity for platinum-based chemotherapy.

doi:10.1080/17425255.2021.1879048

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Erythropoietin promoter polymorphism is associated with treatment efficacy and severe hematologic toxicity for platinum-based chemotherapy.

Expert opinion on drug metabolism & toxicology - 1 Apr 2021

Zheng Yi, Deng Zheng, Tang Mimi, Cai Pei

Abstract excerpt

Background: Erythropoietin (EPO) plays a substantial role in cancer development and probably affects clinical outcomes. A functional polymorphism (rs1617640, G > T) in the promoter region of the EPO increases protein expression. This study investigated the association of EPO rs1617640 with treatment efficacy and severe toxicity in non-small cell lung cancer (NSCLC) patients undergoing platinum-based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Age Factors

Share to Antineoplastic Combined Chemotherapy Protocols

Share to Carcinoma, Non-Small-Cell Lung

Share to Cisplatin

Share to Erythropoietin

Share to Hematologic Diseases

Share to Severity of Illness Index

Share to Sex Factors

Source

Open in PubMed

Identifiers

PMID: 33461346
DOI: 10.1080/17425255.2021.1879048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Erythropoietin promoter polymorphism is associated with treatment efficacy and severe hematologic toxicity for platinum-based chemotherapy.PMID 33461346Read ↗

The functional polymorphism of erythropoietin gene rs1617640 G>T is not associated with susceptibility and clinical outcome of early-stage breast cancer.Semantic proximity Read ↗

XBP1 promoter polymorphism modulates platinum-based chemotherapy gastrointestinal toxicity for advanced non-small cell lung cancer patients.Semantic proximity Read ↗

HIF1α genetic variants and protein expressions determine the response to platinum based chemotherapy and clinical outcome in patients with advanced NSCLC.Semantic proximity Read ↗

Erythropoietin as a Potential Prognostic Biomarker Correlated With Immune Infiltration in Hepatocellular CarcinomaSemantic proximity Read ↗

Impact of the Copper Transporter Protein 1 (CTR1) Polymorphism on Adverse Events among Advanced NonSmall Cell Lung Cancer Patients Treated with a Carboplatin/Gemcitabine Regimen.Semantic proximity Read ↗

Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome.Semantic proximity Read ↗

ERCC1, XRCC1, and GSTP1 Polymorphisms and Treatment Outcomes of Advanced Epithelial Ovarian Cancer Patients Treated with Platinum-based Chemotherapy.Semantic proximity Read ↗

Association of erythropoietin gene rs576236 polymorphism and risk of adrenal tumors in a Chinese populationSemantic proximity Read ↗

The association between COX-2 polymorphisms and hematologic toxicity in patients with advanced non-small-cell lung cancer treated with platinum-based chemotherapy.Semantic proximity Read ↗

Genetically predicted plasma erythropoietin levels and clonal haematopoiesis risk: a Mendelian randomisation studySemantic proximity Read ↗

EPO rs1617640 A>C is a protective factor for chronic obstructive pulmonary disease: a case control studySemantic proximity Read ↗

EPO rs1617640 A>C is a Protective Factor for Chronic Obstructive Pulmonary Disease: A Case Control Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.