Article
The epithelial-mesenchymal transition phenotype is associated with the frequency of tumor spread through air spaces (STAS) and a High risk of recurrence after resection of lung carcinoma.
Lung cancer (Amsterdam, Netherlands) - 1 Mar 2021
Ikeda Toshihiro, Kadota Kyuichi, Yoshida Chihiro, Ishikawa Ryou, Go Tetsuhiko, Haba Reiji, Yokomise Hiroyasu
Abstract excerpt
OBJECTIVES: The prognostic value of spread through air spaces (STAS) in lung carcinoma has been validated in independent cohorts. Epithelial-mesenchymal transition (EMT) is a biological process that promotes the migration and invasiveness of tumor cells. To investigate the role of the EMT phenotype in the occurrence of STAS, we analyzed patients with therapy-naive lung adenocarcinoma and squamous cell carcinoma...
Topics
- Adenocarcinoma of Lung
- Epithelial-Mesenchymal Transition
- Humans
- Lung
- Lung Neoplasms
- Neoplasm Invasiveness
- Neoplasm Recurrence, Local
- Phenotype
- Prognosis
- Retrospective Studies