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Article

Differential prevalence and prognostic significance of spread through air spaces according to oncogenic driver mutations in lung adenocarcinoma.

The Journal of thoracic and cardiovascular surgery - 1 Jun 2026

Lee Jeonghyo, Han Yeon Bi, Kim Sungjin, Kwon Hyun Jung, Kim Hyojin, Kim Kwhanmien, Chung Jin-Haeng

Abstract excerpt

OBJECTIVE: We aimed to characterize the variation in spread through air spaces prevalence by oncogenic driver mutation status in lung adenocarcinoma and to examine whether the prognostic impact of spread through air spaces differs according to driver mutation status. METHODS: In 4027 surgically resected primary nonmucinous lung adenocarcinomas, we analyzed the prevalence of spread through air spaces according to...

Topics

Prognosis
Lung Neoplasms
Prevalence
Adenocarcinoma of Lung
ErbB Receptors
Mutation
Neoplasm Recurrence, Local
Proto-Oncogene Proteins p21(ras)
Neoplasm Invasiveness
Neoplasm Staging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Biomarkers, Tumor

Air

Tumor Burden

Risk Factors

Humans

Male

Female

Middle Aged

Source

Identifiers

PMID: 41520721
DOI: 10.1016/j.jtcvs.2025.12.027

Genes

EGFR
ALK
KRAS
ROS1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-41520721-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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