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Spread through air spaces in lung cancer: From controversy to consensus.

Critical reviews in oncology/hematology - 1 May 2026

Qin Lili, Zhang Rui, Bai Yu, Zhang Hong, Li Wensheng, Zhu Jianfei, Wang Wuping, Ma Yu

Abstract excerpt

In 2015, the concept of Spread Through Air Spaces (STAS) was introduced by the World Health Organization (WHO), which is defined as the dissemination of micropapillary clusters, solid nests, and/or individual cancer cells into the airspace of the lung parenchyma beyond the main tumor edge, was introduced by the WHO. In this study, we comprehensively reviewed the evolution and clinical value of STAS in lung...

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PMID: 41794161
DOI: 10.1016/j.critrevonc.2026.105250

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ALK
EGFR

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