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Article

Cu, Fe, and Zn isotope ratios in murine Alzheimer's disease models suggest specific signatures of amyloidogenesis and tauopathy.

The Journal of biological chemistry - 1 Jan 2000

Solovyev Nikolay, El-Khatib Ahmed H, Costas-Rodríguez Marta, Schwab Karima, Griffin Elizabeth, Raab Andrea, Platt Bettina, Theuring Franz, Vogl Jochen, Vanhaecke Frank

Abstract excerpt

Alzheimer's disease (AD) is characterized by accumulation of tau and amyloid-beta in the brain, and recent evidence suggests a correlation between associated protein aggregates and trace elements, such as copper, iron, and zinc. In AD, a distorted brain redox homeostasis and complexation by amyloid-beta and hyperphosphorylated tau may alter the isotopic composition of essential mineral elements. Therefore,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33453282
DOI: 10.1016/j.jbc.2021.100292
PMCID: PMC7949056

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