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Article

Extension of SKAT to multi-category phenotypes through a geometrical interpretation.

European journal of human genetics : EJHG - 1 May 2021

Bocher Ozvan, Marenne Gaelle, Tournier-Lasserve Elisabeth, Génin Emmanuelle, Perdry Hervé

Abstract excerpt

Rare genetic variants are expected to play an important role in disease and several statistical methods have been developed to test for disease association with rare variants, including variance-component tests. These tests however deal only with binary or continuous phenotypes and it is not possible to take advantage of a suspected heterogeneity between subgroups of patients. To address this issue, we extended...

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Identifiers

PMID: 33446828
DOI: 10.1038/s41431-020-00792-8
PMCID: PMC8110546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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