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Article

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

14 Jan 2021

Abstract excerpt

To date, there is no representative in vitro model for liver sinusoidal endothelial cells (LSECs), as primary LSECs dedifferentiate very fast in culture and no combination of cytokines or growth factors can induce an LSEC fate in (pluripotent stem cell (PSC)-derived) endothelial cells (ECs). Furthermore, the transcriptional programmes driving an LSEC fate have not yet been described. Here, we first present a...

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PMID: 33446637
DOI: 10.1038/s41419-020-03356-2

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