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Article

Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.

Nature - 1 Sept 2016

Dhawan Neil S, Scopton Alex P, Dar Arvin C

Abstract excerpt

Deregulation of the Ras-mitogen activated protein kinase (MAPK) pathway is an early event in many different cancers and a key driver of resistance to targeted therapies. Sustained signalling through this pathway is caused most often by mutations in K-Ras, which biochemically favours the stabilization of active RAF signalling complexes. Kinase suppressor of Ras (KSR) is a MAPK scaffold that is subject to...

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Identifiers

PMID: 27556948
DOI: 10.1038/nature19327
PMCID: PMC5161575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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