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Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes

12 Jan 2021

Abstract excerpt

Genome-wide association studies (GWAS) have discovered numerous genetic variants associated with human behavioural traits. However, behavioural traits are subject to misreports and longitudinal changes (MLC) which can cause biases in GWAS and follow-up analyses. Here, we demonstrate that individuals with higher disease burden in the UK Biobank (n = 455,607) are more likely to misreport or reduce their alcohol...

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PMID: 33436567
DOI: 10.1038/s41467-020-20237-6

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