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Article

Mild cognitive impairment in novel SPG11 mutation-related sporadic hereditary spastic paraplegia with thin corpus callosum: case series.

BMC neurology - 11 Jan 2021

Li Chuan, Yan Qi, Duan Feng-Ju, Zhao Chao, Zhang Zhuo, Du Ying, Zhang Wei

Abstract excerpt

BACKGROUND: SPG11 mutation-related autosomal recessive hereditary spastic paraplegia with thin corpus callosum (HSP-TCC) is the most common cause in complicated forms of HSP, usually presenting comprehensive mental retardation on early-onset stage preceding spastic paraplegias in childhood. However, there are many instances of sporadic late-onset HSP-TCC cases with a negative family history, and potential mild...

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Identifiers

PMID: 33430805
DOI: 10.1186/s12883-020-02040-4
PMCID: PMC7798194

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