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PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential

17 Dec 2020

Abstract excerpt

PD-1/PD-L1 immune checkpoint inhibitors show potential for cervical cancer treatment. However, low response rates suggest that patient selection based on PD-L1 protein expression is not optimal. Here, we evaluated different PD-L1 detection methods and studied transcriptional regulation of PD-L1/PD-L2 expression by The Cancer Genome Atlas (TCGA) mRNAseq analysis. First, we determined the copy number of the...

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PMID: 33424844
DOI: 10.3389/fimmu.2020.596825

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