Article
Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2016
Heeren A Marijne, Punt Simone, Bleeker Maaike Cg, Gaarenstroom Katja N, van der Velden Jacobus, Kenter Gemma G, de Gruijl Tanja D, Jordanova Ekaterina S
Abstract excerpt
Programmed death-ligand 1 (PD-L1) is expressed in various immune cells and tumor cells, and is able to bind to PD-1 on T lymphocytes, thereby inhibiting their function. At present, the PD-1/PD-L1 axis is a major immunotherapeutic target for checkpoint inhibition in various cancer types, but information on the clinical significance of PD-L1 expression in cervical cancer is largely lacking. Here, we studied PD-L1...
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