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Can we truly diagnose adult secondary hemophagocytic lymphohistiocytosis (HLH)? A critical review of current paradigms.

Pathology, research and practice - 1 Feb 2021

Naymagon Leonard

Abstract excerpt

The HLH-2004 criteria were initially conceived as inclusion criteria for a clinical trial investigating therapy for (largely primary) pediatric hemophagocytic lymphohistiocytosis (HLH). These criteria have since been extrapolated to diagnose adult secondary HLH despite their questionable generalizability. It remains unclear whether these diagnostic criteria are truly applicable among adult secondary cases, and...

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PMID: 33418346
DOI: 10.1016/j.prp.2020.153321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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