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Article

Ferroptosis induces membrane blebbing in placental trophoblasts

7 Jan 2021

Abstract excerpt

Ferroptosis is a regulated, non-apoptotic form of cell death, characterized by hydroxy-peroxidation of discrete phospholipid hydroperoxides, particularly hydroperoxyl (Hp) forms of arachidonoyl- and adrenoyl-phosphatidylethanolamine, with a downstream cascade of oxidative damage to membrane lipids, proteins and DNA, culminating in cell death. We recently showed that human trophoblasts are particularly sensitive...

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PMID: 33414166
DOI: 10.1242/jcs.255737

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