Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies.

doi:10.1007/s10875-020-00952-x

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Article

Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies.

Journal of clinical immunology - 1 Apr 2021

Lodi Lorenzo, Melki Isabelle, Bondet Vincent, Seabra Luis, Rice Gillian I, Carter Edwin, Lepelley Alice, Martin-Niclós Maria José, Al Adba Buthaina, Bader-Meunier Brigitte, Barth Magalie, Blauwblomme Thomas, Bodemer Christine, Boespflug-Tanguy Odile, Dale Russel C, Desguerre Isabelle, Ducrocq Camille, Dulieu Fabienne, Dumaine Cécile, Ellul Pierre, Hadchouel Alice, Hentgen Véronique, Hié Miguel, Hully Marie, Jeziorski Eric, Lévy Romain, Mochel Fanny, Orcesi Simona, Passemard Sandrine, Pouletty Marie, Quartier Pierre, Renaldo Florence, Seidl Rainer, Shetty Jay, Neven Bénédicte, Blanche Stéphane, Duffy Darragh, Crow Yanick J, Frémond Marie-Louise

Abstract excerpt

Whilst upregulation of type I interferon (IFN) signaling is common across the type I interferonopathies (T1Is), central nervous system (CNS) involvement varies between these disorders, the basis of which remains unclear. We collected cerebrospinal fluid (CSF) and serum from patients with Aicardi-Goutières syndrome (AGS), STING-associated vasculopathy with onset in infancy (SAVI), presumed monogenic T1Is (pT1I),...

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PMID: 33411153
DOI: 10.1007/s10875-020-00952-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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