Article
Interferon-related transcriptome alterations in the cerebrospinal fluid cells of Aicardi-Goutières patients.
Brain pathology (Zurich, Switzerland) - 1 Oct 2009
Izzotti Alberto, Pulliero Alessandra, Orcesi Simona, Cartiglia Cristina, Longobardi Maria G, Capra Valeria, Lebon Pierre, Cama Armando, La Piana Roberta, Lanzi Giovanni, Fazzi Elisa
Abstract excerpt
Aicardi-Goutières syndrome (AGS) is a rare interferon (IFN)-related encephalopathy with onset during the first year of life. AGS, is clinically characterized by progressive microcephaly, bilateral basal ganglia calcification, cerebral atrophy, cerebrospinal fluid (CSF), lymphocytosis, delayed development of psychomotor abilities with pyramidal-extrapyramidal syndrome and mimics congenital viral infections....
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