Pharmacogenetics of advanced lung cancer: Predictive value of functional genetic polymorphism AGXT Pro11Leu in clinical outcome?

doi:10.1016/j.pulmoe.2020.11.007

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Article

Pharmacogenetics of advanced lung cancer: Predictive value of functional genetic polymorphism AGXT Pro11Leu in clinical outcome?

Pulmonology - 1 Jan 2000

Catarata Maria Joana, Lourenço Margarida, Martins Maria Fátima, Frade João, Pêgo Alice, Cordeiro Carlos Robalo, Medeiros Rui, Ribeiro Ricardo

Abstract excerpt

INTRODUCTION: AGXT gene codes for the enzyme alanine glyoxylate aminotransferase, which is involved in hepatic peroxisomal metabolism of platinum-based chemotherapeutic agents. The association of genetic variant AGXT rs34116584 on the clinical outcome and response to chemotherapy of patients with non-small cell lung cancer (NSCLC) remains to be established. Our aim was to evaluate the association of functional...

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PMID: 33408043
DOI: 10.1016/j.pulmoe.2020.11.007

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