Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort.

BMC medical genomics - 6 Jan 2021

Rosenthal Elisabeth A, Crosslin David R, Gordon Adam S, Carrell David S, Stanaway Ian B, Larson Eric B, Grafton Jane, Wei Wei-Qi, Denny Joshua C, Feng Qi-Ping, Shah Amy S, Sturm Amy C, Ritchie Marylyn D, Pacheco Jennifer A, Hakonarson Hakon, Rasmussen-Torvik Laura J, Connolly John J, Fan Xiao, Safarova Maya, Kullo Iftikhar J, Jarvik Gail P

Abstract excerpt

BACKGROUND: Elevated triglycerides (TG) are associated with, and may be causal for, cardiovascular disease (CVD), and co-morbidities such as type II diabetes and metabolic syndrome. Pathogenic variants in APOA5 and APOC3 as well as risk SNVs in other genes [APOE (rs429358, rs7412), APOA1/C3/A4/A5 gene cluster (rs964184), INSR (rs7248104), CETP (rs7205804), GCKR ()] have been shown to affect TG levels....

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Cohort Studies
Share to C3 gene
Share to Genetic Predisposition to Disease
Share to Hypertriglyceridemia
Share to Polymorphism, Single Nucleotide
Share to Risk Factors
Share to Triglycerides

Source

Open in PubMed Open full text

Identifiers

PMID: 33407432
DOI: 10.1186/s12920-020-00854-2
PMCID: PMC7789246

Genes

TG
SLC25A40
APOA1
APOA5
APOC3
APOE
C3
CETP
GCKR
INSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort.PMID 33407432Read ↗

Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestrySemantic proximity Read ↗

Joint linkage and association analysis with exome sequence data implicates SLC25A40 in hypertriglyceridemia.Semantic proximity Read ↗

Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes.Semantic proximity Read ↗

Genetic Variants in Severe Hypertriglyceridemia Among Taiwanese Participants - Insights From Genome-Wide Association and Whole-Exome Sequencing Analyses.Semantic proximity Read ↗

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.Semantic proximity Read ↗

Integrative exome sequencing and multi-omics analysis elucidates the regulatory role of rare variants in metabolic syndrome.Semantic proximity Read ↗

Ancestry-specific profiles of genetic determinants of severe hypertriglyceridemia.Semantic proximity Read ↗

Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada PopulationSemantic proximity Read ↗

Comprehensive evaluation of the association of APOE genetic variation with plasma lipoprotein traits in U.S. whites and African blacks.Semantic proximity Read ↗

Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.Semantic proximity Read ↗

Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families.Semantic proximity Read ↗

Genetic determinants of plasma triglycerides.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.