Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.

doi:10.1038/ng.628

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Article

Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.

Nature genetics - 1 Aug 2010

Johansen Christopher T, Wang Jian, Lanktree Matthew B, Cao Henian, McIntyre Adam D, Ban Matthew R, Martins Rebecca A, Kennedy Brooke A, Hassell Reina G, Visser Maartje E, Schwartz Stephen M, Voight Benjamin F, Elosua Roberto, Salomaa Veikko, O'Donnell Christopher J, Dallinga-Thie Geesje M, Anand Sonia S, Yusuf Salim, Huff Murray W, Kathiresan Sekar, Hegele Robert A

Abstract excerpt

Genome-wide association studies (GWAS) have identified multiple loci associated with plasma lipid concentrations. Common variants at these loci together explain <10% of variation in each lipid trait. Rare variants with large individual effects may also contribute to the heritability of lipid traits; however, the extent to which rare variants affect lipid phenotypes remains to be determined. Here we show an...

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Identifiers

PMID: 20657596
DOI: 10.1038/ng.628
PMCID: PMC3017369

Genes

APOA5
APOB
GCKR
LPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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