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Article

Ancestry-specific profiles of genetic determinants of severe hypertriglyceridemia.

Journal of clinical lipidology - 1 Jan 2000

Gill Praneet K, Dron Jacqueline S, Dilliott Allison A, McIntyre Adam D, Cao Henian, Wang Jian, Movsesyan Irina G, Malloy Mary J, Pullinger Clive R, Kane John P, Hegele Robert A

Abstract excerpt

BACKGROUND: Susceptibility to severe hypertriglyceridemia (HTG), defined as plasma triglyceride (TG) levels ≥10 mmol/L (880 mg/dL), is conferred by both heterozygous rare variants in five genes involved in TG metabolism and numerous common single-nucleotide polymorphisms (SNPs) associated with TG levels. OBJECTIVE: To date, these genetic susceptibility factors have been comprehensively assessed primarily in...

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Apolipoprotein A-V
Apolipoprotein C-II
East Asian People
Hispanic or Latino
Hypertriglyceridemia

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Lipoprotein Lipase

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PMID: 33303403
DOI: 10.1016/j.jacl.2020.11.007

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