Article
Novel RANKL DE-loop mutants antagonize RANK-mediated osteoclastogenesis.
The FEBS journal - 1 Aug 2017
Wang Yizhou, van Assen Aart H G, Reis Carlos R, Setroikromo Rita, van Merkerk Ronald, Boersma Ykelien L, Cool Robbert H, Quax Wim J
Abstract excerpt
Bone is a dynamic tissue that is maintained by continuous renewal. An imbalance in bone resorption and bone formation can lead to a range of disorders, such as osteoporosis. The receptor activator of NF-κB (RANK)-RANK-ligand (RANKL) pathway plays a major role in bone remodeling. Here, we investigated the effect of mutations at position I248 in the DE-loop of murine RANKL on the interaction of RANKL with RANK, and...
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