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Article

Exploring the Genetic Association of the ABAT Gene with Alzheimer's Disease.

Molecular neurobiology - 1 May 2021

Zheng Quanzhen, Bi Rui, Xu Min, Zhang Deng-Feng, Tan Li-Wen, Lu Ya-Ping, Yao Yong-Gang

Abstract excerpt

Accumulating evidence demonstrated that GABAergic dysfunction contributes to the pathogenesis of Alzheimer's disease (AD). The GABA aminotransferase (ABAT) gene encodes a mitochondrial GABA transaminase and plays key roles in the biogenesis and metabolism of gamma-aminobutyric acid (GABA), which is a major inhibitory neurotransmitter. In this study, we performed an integrative study at the genetic and expression...

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PMID: 33404980
DOI: 10.1007/s12035-020-02271-z

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