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Article

Multimorbidity burden and dementia risk in older adults: The role of inflammation and genetics.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2021

Grande Giulia, Marengoni Alessandra, Vetrano Davide L, Roso-Llorach Albert, Rizzuto Debora, Zucchelli Alberto, Qiu Chengxuan, Fratiglioni Laura, Calderón-Larrañaga Amaia

Abstract excerpt

INTRODUCTION: We investigate dementia risk in older adults with different disease patterns and explore the role of inflammation and apolipoprotein E (APOE) genotype. METHODS: A total of 2,478 dementia-free participants with two or more chronic diseases (ie, multimorbidity) part of the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) were grouped according to their multimorbidity patterns and...

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Aged, 80 and over
Apolipoprotein E4
C-Reactive Protein
Cohort Studies
Dementia

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PMID: 33403740
DOI: 10.1002/alz.12237
PMCID: PMC8247430

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