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Article

The Role of Efflux Pumps in Schistosoma mansoni Praziquantel Resistant Phenotype.

PloS one - 1 Jan 2015

Pinto-Almeida António, Mendes Tiago, Armada Ana, Belo Silvana, Carrilho Emanuel, Viveiros Miguel, Afonso Ana

Abstract excerpt

BACKGROUND: Schistosomiasis is a neglected disease caused by a trematode of the genus Schistosoma that is second only to malaria in public health significance in Africa, South America, and Asia. Praziquantel (PZQ) is the drug of choice to treat this disease due to its high cure rates and no significant side effects. However, in the last years increasingly cases of tolerance to PZQ have been reported, which has...

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PMID: 26445012
DOI: 10.1371/journal.pone.0140147
PMCID: PMC4596880

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