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Neuropsychiatric symptoms are early indicators of an upcoming metabolic decline in Alzheimer's disease.

Translational neurodegeneration - 4 Jan 2021

Ng Kok Pin, Pascoal Tharick A, Mathotaarachchi Sulantha, Chan Yiong Huak, Jiang Lai, Therriault Joseph, Benedet Andrea L, Shin Monica, Kandiah Nagaendran, Greenwood Celia M T, Rosa-Neto Pedro, Gauthier Serge

Abstract excerpt

BACKGROUND: Neuropsychiatric symptoms (NPS) are increasingly recognized as early non-cognitive manifestations in the Alzheimer's disease (AD) continuum. However, the role of NPS as an early marker of pathophysiological progression in AD remains unclear. Dominantly inherited AD (DIAD) mutation carriers are young individuals who are destined to develop AD in future due to the full penetrance of the genetic...

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PMID: 33390174
DOI: 10.1186/s40035-020-00225-y
PMCID: PMC7780680

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NPS

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