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Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures

15 Dec 2020

Abstract excerpt

Deep sequencing of B cell receptor (BCR) heavy chains from a cohort of 31 COVID-19 patients from the UK reveals a stereotypical naive immune response to SARS-CoV-2 which is consistent across patients. Clonal expansion of the B cell population is also observed and may be the result of memory bystander effects. There was a strong convergent sequence signature across patients, and we identified 1,254 clonotypes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33384691
DOI: 10.3389/fimmu.2020.605170

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