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Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation

15 Dec 2020

Abstract excerpt

Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could have promising therapeutic implications for patients carrying GRN mutations. In this study, we explored the therapeutic potential of sortilin1 (SORT1), a clearance receptor of PGRN, by generating and characterizing monoclonal...

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PMID: 33384578
DOI: 10.3389/fnins.2020.586107

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